Genome-Wide Association Studies and Beyond
نویسندگان
چکیده
منابع مشابه
Advances in Genetics Moving Beyond Genome-Wide Association Studies
The sequencing of the human genome1 and the subsequent completion of the human haplotype mapping (HapMap) project2 have led to unparalleled research into the structure and biology of the genome. These milestones held the promise of revolutionizing our understanding of the genetic basis for human disease, with the hope that population research would quickly lead to improved screening and diagnos...
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Atherosclerotic diseases, including coronary artery disease (CAD) and myocardial infarction (MI), are the leading causes of death in the world. The genetic basis of CAD and MI, which are caused by multiple interacting endogenous and exogenous factors, has gained considerable interest in the last years as genome-wide association studies (GWASs) have identified many new susceptibility loci for CA...
متن کاملGenome-wide Association Studies
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
متن کاملGenome-wide Association Studies
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
متن کاملGenome-wide association studies.
Genome-wide association (GWA) studies are best understood as an extension of candidate gene association studies, scaled up to cover hundreds of thousands of markers across the genome in samples usually of several thousand cases and controls. The GWA approach allows the detection of much smaller effect sizes than with previous linkage-based genome-wide studies. However, this sensitivity makes th...
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ژورنال
عنوان ژورنال: Annual Review of Public Health
سال: 2010
ISSN: 0163-7525,1545-2093
DOI: 10.1146/annurev.publhealth.012809.103723